Ectoparasites: Drug Discovery Against Moving Targets (Drug Discovery in Infectious Diseases) – Charles Q. Meng, Ann E. Sluder, Paul M. Selzer

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This first book specifically dedicated to ectoparasite drug discovery is unique in providing insights from the veterinary as well as the medical perspective, covering research from both industry and academia while paving the way for new synergies between the two research communities. Edited by a team combining 80 years of experience in academic research and industrial antiparasitic drug discovery, this volume of Drug Discovery in Infectious Diseases summarizes current knowledge in this rapidly expanding field.

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Comprehensive yet concise, this ready reference blends solid background information on ectoparasite biology with the very latest methods in ectoparasite drug discovery. Three major parts cover current ectoparasite control strategies and the threat of drug resistance, screening and drug evaluation, and the new isoxazoline class of ectoparasiticides. The future potential of mechanism-based approaches for repellents and parasiticides is thoroughly discussed, as are strategies for vaccines against ectoparasites, making the book ideal for parasitologists in academia as well as researchers working in the pharmaceutical industry.
 
List of Contributors VII Foreword XIII Preface XV Part One Strategies & Resistance 1 1 Comparison of Anti-ectoparasite and Anti-endoparasite Therapies and Control Strategies 3 Debra J. Woods*, Tom L. McTier, and Andrew A. DeRosa 2 vaccination Against Ticks 25 Theo P.M. Schetters* 3 Blocking Transmission of vector-borne Diseases  43 Sandra Schorderet-Weber, Sandra Noack, Paul M. Selzer, and Ronald Kaminsky* 4 The Threat and Reality of Drug Resistance in the Cattle Tick Rhipicephalus (Boophilus) microplus  95 Heinz Sager*, Léonore Lovis, Christian Epe, and Ronald Kaminsky 5 Monitoring Drug Sensitivity in Cattle Ticks 109 Leonore Lovis, Christian Epe, Ronald Kaminsky, and Heinz Sager* 6 New Developments in the Control of Human Lice 119 John M. Clark* Part Two Screens & Models 139 7 Molecular Targets to Impair Blood Meal Processing in Ticks 141 Petr Kopáček*, Jan Perner, Daniel Sojka, Radek Šíma, and Ondřej Hajdušek 8 Whole-organism Screens for Ectoparasites 167 Jeffrey N. Clark* and Cedric J. Pearce 9 In vitro Feeding Methods for Hematophagous Arthropods and Their Application in Drug Discovery 187 Ard M. Nijhof* and Katharine R. Tyson 10 Testing in Laboratory Animal Models for Ectoparasiticide Discovery and Development 205 Sandra Schorderet-Weber* and Ronald Kaminsky 11 Testing in Target Hosts for Ectoparasiticide Discovery and Development 223 Jeffrey N. Clark* Part Three Isoxazolines 243 12 Isoxazolines: A Novel Chemotype Highly Effective on Ectoparasites 245 Tina Weber and Paul M. Selzer* 13 The Discovery of Afoxolaner: A New Ectoparasiticide for Dogs  259 Ming Xu, Jeffrey K. Long, George P. Lahm*, Wesley L. Shoop, Daniel Cordova, Ty Wagerle, Ben K. Smith, Thomas F. Pahutski, Rafael Shapiro, Michael Mahaffey, Eric J. Hartline, Brandon R. Gould, Molly E. Waddell, Richard G. McDowell, John B. Kinney, Gail S. Jones, Robert F. Dietrich, Mark E. Schroeder, Daniel F. Rhoades, Eric A. Benner, and Pat N. Confalone 14 Development of Afoxolaner as a New Ectoparasiticide for Dogs 273 Laura Letendre*, Diane Larsen, and Mark Soll 15 Discovery, Development, and Commercialization of Sarolaner (Simparica®), A Novel Oral Isoxazoline Ectoparasiticide for Dogs 295 Debra J. Woods* and Tom L. McTier 16 Isoxazolines: Preeminent Ectoparasiticides of the Early Twenty-first Century 319 Alan Long* Index 353
  • Vazba: pevná
  • Počet stran: 376
  • Nakladatel: Wiley VCH (11 July 2018)
  • Jazyk: angličtina
  • ISBN-10: 3527341684
  • ISBN-13: 978-3527341689
  • Rozměry: 17 x 2 x 24.9 cm

Doplňkové parametry

Kategorie: Farmakologie & toxikologie & chemie
Jazyk: angličtina
Vazba: pevná
Počet stran: 376
Nakladatel: Wiley-Blackwell, 2018
ISBN: 9783527341689
Rozměry:

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