Veterinary Pharmacology and Therapeutics – Jim E. Riviere, Mark G. Papich

Contributors    xiii Preface    xix About the Companion Website    xxi Section AEI Principles of Pharmacology   1 Veterinary Pharmacology: An Introduction to the Discipline   3 Jim E. Riviere and Mark G. Papich Absorption, Distribution, Metabolism, and Elimination   8 Jim E. Riviere Pharmacokinetics   41 Jim E. Riviere Mechanism of Drug Action and Pharmacokinetics/ Pharmacodynamics Integration in Dosage Regimen Optimization for Veterinary Medicine   65 Pierre-Louis Toutain Principles of Pharmaceutics and Veterinary Dosage Forms   87 Raafat M. Fahmy and Marilyn N. Martinez Section f Drugs Acting on the Autonomic Nervous System   111 Introduction to the Autonomic Nervous Systemand Autonomic Pharmacology   113 Joshua A. Rowe, RoseM.McMurphy, Barbara J. Lutjemeier, andMichael J. Kenney Adrenergic Receptor Agonists and Antagonists   131 Rose M.McMurphy, Elizabeth G. Davis, Amy J. Rankin, Daniel A. Frese, Barbara J. Lutjemeier, and Michael J. Kenney Cholinergic Pharmacology: Autonomic Drugs   151 RoseM.McMurphy, Elizabeth G. Davis, Amy J. Rankin,Marjory A. Artzer, Barbara J. Lutjemeier, andMichael J. Kenney Section g Anesthetics and Analgesics, and Drugs Acting on the Central Nervous System   165 Introduction to Drugs Acting on the Central Nervous Systemand Principles of Anesthesiology 167 Peter J. Pascoe and Eugene P. Steffey Neuromuscular Blocking Agents  194 Diane E.Mason and Christopher L. Norkus Inhalation Anesthetics   216 Robert J. Brosnan and Eugene P. Steffey Injectable Anesthetic Agents   247 Lysa P. Posner Opioid Analgesic Drugs   281 Butch KuKanich andMark G. Papich Sedatives and Tranquilizers   324 Lysa P. Posner Local Anesthetics   369 Thomas W. Vickroy Euthanizing Agents   387 Anna Hampton Anticonvulsant Drugs   395 Mark G. Papich Drugs Affecting Animal Behavior   416 Margaret E. Gruen, Barbara L. Sherman, and Mark G. Papich Section h Autacoids and Antiinflammatory Drugs   449 Histamine, Serotonin, and their Antagonists   451 Wolfgang B¨aumer Analgesic, Antiinflammatory, Antipyretic Drugs   467 Peter Lees Section i Drugs Acting on the Cardiovascular System 501 Digitalis, Positive Inotropes, and Vasodilators   503 Clarke E. Atkins and Marisa K. Ames Antiarrhythmic Agents   537 Kathryn M. Meurs and Jim E. Riviere Section j Drugs Affecting Renal Function and Fluid–Electrolyte Balance   553 Principles of Acid–Base Balance: Fluid and Electrolyte Therapy, Blood Substitutes    555 Maya M. Scott-Garrard, Melisa Rosenthal, and Deborah T. Kochevar Diuretics and Renal Pharmacology   593 Butch Kukanich and Deborah T. Kochevar Section k Drugs Acting on Blood and Blood Elements   623 Anticoagulant, Antiplatelet, and Hemostatic Drugs   625 Mark G. Papich Section l Endocrine Pharmacology   647 Hypothalamic and Pituitary Hormones   649 Srujana Rayalam,Margarethe Hoenig, and Duncan C. Ferguson Hormones Affecting Reproduction   674 Wolfgang B¨aumer, C. Scott Bailey, and John Gadsby Thyroid Hormone and Antithyroid Drugs   691 Duncan C. Ferguson Glucocorticoids, Mineralocorticoids, and Adrenolytic Drugs   729 Duncan C. Ferguson and Margarethe Hoenig Drugs Influencing Glucose Metabolism   763 Margarethe Hoenig Chemotherapy of Microbial Diseases   779 Antiseptics and Disinfectants   781 Megan E. Jacob Sulfonamides and Potentiated Sulfonamides   796 Mark G. Papich -Lactam Antibiotics: Penicillins, Cephalosporins, and Related Drugs   826 Mark G. Papich Tetracycline Antibiotics   858 Mark G. Papich and Jim E. Riviere Aminoglycoside Antibiotics   877 Mark G. Papich and Jim E. Riviere Chloramphenicol and Derivatives, Macrolides, Lincosamides, andMiscellaneous Antimicrobials   903 Mark G. Papich Fluoroquinolone Antimicrobial Drugs   953 Mark G. Papich Antifungal and Antiviral Drugs   988 Jennifer L. Davis and LaraMaxwell Section AEIe Chemotherapy of Parasitic Diseases  1033 Antinematodal Drugs   1035 Carlos E. Lanusse, JuanM. Sallovitz, Sergio F. Sanchez Bruni, and Luis I. Alvarez Anticestodal and Antitrematodal Drugs   1081 Carlos E. Lanusse, Luis I. Alvarez, and Guillermo L. Virkel Macrocyclic Lactones: Endectocide Compounds   1102 Carlos E. Lanusse, Fernanda A. Imperiale, and Adrian L. Lifschitz Antiprotozoan Drugs   1128 Jennifer L. Davis and Jody L. Gookin Ectoparasiticides   1166 Ronald E. Baynes Section AEIAEI Specialty Areas of Pharmacology   1189 Chemotherapy of Neoplastic Diseases   1191 Luke A.Wittenburg and Daniel L. Gustafson Immunosuppressive Drugs   1226 Mark G. Papich Drugs for Treating Gastrointestinal Diseases   1245 Mark G. Papich Dermatopharmacology: Drugs Acting Locally on the Skin   1278 Jim E. Riviere and Rosanna Marsella Drugs that Affect the Respiratory System   1302 Mark G. Papich Ophthalmic Pharmacology   1321 Alison Clode Pharmacogenomics   1332 Katrina L.Mealey Considerations for TreatingMinor Food-Producing Animals with Veterinary Pharmaceuticals   1345 Lisa A. Tell, Margaret Oeller, Tara Marmulak, and Ronette Gehring Unique Considerations Pertaining to the Use of Drugs in Food Animals   1358 Michael D. Apley Pharmacology in Aquatic Animals   1373 Ron A.Miller Zoological Pharmacology   1395 Robert P. Hunter Section AEIf Regulatory and Other Considerations   1405 The Regulation of Animal Drugs   1407 Steven D. Vaughn andMarilyn N. Martinez Veterinary Pharmacy  1427 Gigi Davidson andMark G. Papich Medication Control Programs in Performance Animals   1439 Cynthia A. Cole Pharmacovigilance   1448 John D. Baker, Susan J. Bright-Ponte, and Lee Anne M. Palmer Dosage Forms And Veterinary Feed Directives   1459 Geof Smith and Jim E. Riviere Evidence-Based Pharmacotherapy   1465 Ronette Gehring Chemical Residues In Tissues Of Food Animals   1469 Jim E. Riviere Index   1481